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How to Evaluate Inflammatory Diseases
Since inflammation is commonly mediated by the gut it is a logical
starting point in the evaluation process of any patient. There are seven
common areas that should be considered when looking at causative
factors for gastrointestinal dysfunction that create the environment for
chronic inflammation. They are listed below along with key triggers
within the category of evaluation:
- Diet: Alcohol, Gluten, Casein, Processed Foods, Sugar, Fast Food
- Medications: Corticosteroids, Antibiotics, Antacids, Xenobiotics
- Infections: Such as H-Pylori, Yeast or Bacterial Overgrowth, Viral or Parasite Infection
- Stress: Increased Cortisol, Increased Catecholamines
- Hormonal: Thyroid, Progesterone, Estradiol, Testosterone
- Neurological: Brain Trauma, Stroke, Neuro-degeneration
- Metabolic: Glycosylated End Products (inflammatory end products of sugar metabolism), Intestinal Inflammation, Autoimmune
Inflammation and Autoimmune Disease
The truth of the situation is that FOOD MATTERS. That’s right, it’s
not just a movie (which by the way you should all watch!).
Hyper-permeability of the gut, regardless of whether you can feel it or
not is often a significant cause of an extremely long and ever growing
list of conditions. The inflammatory cascade that takes place by any
inflammatory trigger (diet, medications, infections, stress, hormonal,
neurological, or metabolic) can break down the intestinal permeability
and allows for the leaky gut mechanism to initiate.
Due to the variety of triggers, it is often possible to reduce an
individual’s immune reactivity but not cure it if leaky gut is not the
primary trigger for the inflammatory process. There are multiple models
of autoimmunity although it is becoming more well accepted that once you
develop autoimmunity you will have increased Intestinal Permeability
also.
Autoimmunity can be put into remission and this can have profound
improved life consequences but it can also be turned on again if life
circumstances change. It is considered "Incurable". You may be able to
change the expression of it but to think that you are going to be able
to take a boat load of supplements and change your diet and cure the
condition you are generally going to be let down.
Waxing and waning responses are par for autoimmunity. When stress
picks up despite dietary intake a person will be expected to flare up.
This inflammation is initiated by increased levels of iNOS (inducible
nitric oxide) which causes an immediate increase in intestinal
permeability much like elevated cortisol levels from stress. Once this
occurs serum protein particles leak through and become extremely
reactive. Gluten is an extremely common serum protein in a situation of
increased permeability simply due to the commonality of daily exposure.
If you take on too many projects, eat poorly, have limited or poor
sleep patterns, then you can bet that intestinal permeability will
increase and food will start to leak through.
Your immune system will then begin to recognize these proteins as
other similar proteins like cerebellum, thyroid, etc... When that occurs
you will experience symptoms that generally are far removed from what
someone would consider to be food related since they are not felt in the
gut. Instead you experience brain fog, pain, fatigue, poor sleep,
anxiety, or endocrine dysfunction. When antibodies combine with our
structural proteins, specific genes are turned on in a special type of
immune cell in the body. Inflammatory chemicals are created called
cytokines, which are strongly damaging to brain function. In fact,
elevated cytokines are seen in such devastating conditions as
Alzheimer's disease, Parkinson's disease, multiple sclerosis and even
autism.
You see, autoimmune disease is not clinically diagnosed until you
have tissue destruction. For some neurodegenerative conditions, you need
up to 70 percent demyelination (nerve damage) before it will show on an
MRI. You cannot afford to wait for that type of advanced destruction
before taking action. If you are symptomatic in any way and show to have
antibodies or test positive on any of the tests listed above, you have
Autoimmune Reactivity and that is enough to take action and make life
changes to potentially stop the process from continuing. Inflammation
can be a great friend in this sense. Look at it as an early warning sign
and take action before it turns into a fire that rages out of control
from one body tissue to another.
Recap & Treatment
Inflammation is rampant. In fact 1 in 12 women and 1 in 24 men are
dealing with full blown autoimmune mediated inflammation. The number of
undiagnosed people is going to be much higher. People with inflammation
in the early phases of autoimmunity will often claim no dietary
involvement. This is an inaccurate assumption however because the
autoimmunity is often triggered by factors not strictly related to diet
and the diet can become a secondary trigger later in the development of
the condition. If you are dealing with inflammation then get a
comprehensive evaluation to look at what is perpetuating your personal
fire.
- Lifestyle: Remove adverse mechanisms (Stress,
Over-exercising, Poor Sleep, Blood Sugar Dysregulation, Poor Social
Behaviors.) Lifestyle factors are huge, the stress response triggers
immune marker IL6 which turns on the immune pathway TH17 which is the
fast track to Autoimmunity.
- Lifestyle: Restore beneficial mechanisms:
Create conditions of love & appreciation, keep positive attitudes,
maintain proper exercise (training to a maximum heart range; i.e. Peak
Fitness exercises), have adequate sleep, restore blood sugar balance,
and facilitate healthy social interactions. All these things promote
natural systemic opioids which pushes the immune pathway TH3 which
reduces Autoimmunity.
- Dietary Support: Stabilize blood sugar, remove
food Autoimmune triggers, and promote intestinal integrity with proper
flora and nitric oxide and glutathione pathways. Include fermented foods
and supplement appropriately as may be needed.
Remember, a wide array of health problems, including but not limited
to chronic pain, obesity, ADD/ADHD, peripheral neuropathy, diabetes,
heart disease, stroke, migraines, thyroid issues, dental issues, and
cancer are all rooted in inflammation, which must be properly addressed
if you wish to be healed.
About the Author
Dr. Marquis is a Chiropractic Physician who is Board Certified in
Clinical Nutrition in San Luis Obispo County, CA. He also holds
certifications in Botanical Medicine, Class IV Laser Therapies,
Manipulation Under Anesthesia, Interactive Metronome Therapies and is
currently pursuing another Diplomate in Functional Neurology.
David M. Marquis, DC, DACBN
Diplomat American Clinical Board of Nutrition
860 Oak Park Blvd. #202
Arroyo Grande, Ca 93420
(805) 481-3499
(805) 481-3498
www.drdavidmarquis.com
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